In this second episode on pediatric clinical trial challenges, Begoña Nafria, pediatrician and patient engagement lead at SJD Barcelona Children’s Hospital (Spain), and Vivienne Van de Walle, pediatrician and Director/Research Physician at the independent research site PreCare Trial & Recruitment (The Netherlands), share their experiences and recommendations on the use of decentralized clinical trial features for pediatric research. Additionally, considering the inclusion of caregivers in pediatric trials, Vivienne and Begoña shed light on the complexities involved in gathering data from caregivers.