In this third episode on pediatric clinical trial challenges, Begoña Nafria, pediatrician and patient engagement lead at SJD Barcelona Children’s Hospital (Spain), and Vivienne Van de Walle, pediatrician and Director/Research Physician at the independent research site PreCare Trial & Recruitment (The Netherlands), bring decades of combined expertise to explore the enduring journey of pediatric clinical trials and the unique challenges faced by the young patients involved.